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KMID : 0355620070330030221
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2007 Volume.33 No. 3 p.221 ~ p.226
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THE EFFECT OF PRP AND FIBRIN SEALANT WITH THE DEPROTENIZED BOVINE BONE IN THE RABBIT CRANIUM
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Lee Yong-In
Shin Seung-Yun
Lee Dong-Hwan
Hong Jong-Rak
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Abstract
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Purpose: The purpose of this study is to evaluation of effect on bone formation of PRP and fibrin sealant with deproteinized bovine bone(Bio-Oss) grafts on rabbit cranial defect.
Material and Methods: Twelve rabbits were used as experimental animal Two equal 9㎜ diameter cranial bone defects were created in each rabbit and immediately grafted with Bio-Oss only, Bio-Oss and PRP, and Bio-Oss and Fibrin sealant. Rabbits were sacrificed at 4 and 8 week. The defects were evaluated by histomorphometric analysis.
Results: Kruskal-Wallis tests were performed comparing new bone formation via histomorphometric analysis. No statistically significant difference of new bone formation was found between Bio-Oss only, Bio-Oss and PRP, and Bio-Oss and fibrin sealant at 4 and 8 weeks (P＞0.05).
Conclusion: This study fails to find a stimulatory effect of PRP and Fibrin sealant on New bone formation of Bio-Oss grafts by histomorphometric analyses.
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KEYWORD
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Bio-Oss, PRP, Fibrin sealant, Deprotenized bovine bone
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